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ORIGINAL ARTICLE
Year : 2015  |  Volume : 14  |  Issue : 2  |  Page : 83-86

Prevalence of glucose-6-phosphate dehydrogenase deficiency among sickle cell patients


Department of Medical Laboratory Science, School of Basic Medical Science, College of Medical Science, University of Benin, Nigeria

Correspondence Address:
Osime Evarista Odaburhine
Department of Medical Laboratory Science, School of Basic Medical Science, College of Medical Science, University of Benin
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2384-5589.170160

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Background: Anemia is one of the important clinical significance in sickle cell disease, and a major clinical consequence of glucose-6-phosphate dehydrogenase (G6PD) deficiency is hemolytic anemia. The aim of this study is to compare the enzyme activity in sickle cell patients (SS) and normal hemoglobin (Hb) (AA) individuals. Patients and Methods: A total of 100 hundred samples comprised of 50 sickle cell patients as test subjects and 50 Hb AA individuals were used as controls. Each of the blood sample collected was screened immediately for G6PD deficiency using the methemoglobin reduction test and Randox kit. Results obtained were subjected to statistical analysis using paired t-test. Result: Glucose-6-phosphate dehydrogenase deficiency was found to be significantly higher in test subjects (P < 0.01) when compared with the control subjects. It was also shown that G6PD levels tend to increase with increase in age though this increase was not significant (P > 0.05). There was no significant difference in G6PD levels between males and females sickle cell patients (P > 0.05). Conclusion: These results, therefore, suggests that G6PD enzyme activity is much more reduced in the sickle cell patient who may contribute to making them prone to hemolytic anemia when compared to normal individuals.


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