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ORIGINAL ARTICLE
Year : 2013  |  Volume : 12  |  Issue : 1  |  Page : 1-5

Serum sodium, potassium, calcium and magnesium in women with pregnancy induced hypertension and preeclampsia in Oredo local Government, Benin Metropolis: A pilot study


Department of Chemical Pathology, University of Benin, Benin City, Edo State, Nigeria

Correspondence Address:
Olanike Funmilola Adewolu
Department of Chemical Pathology, University of Benin, Benin City, Edo State
Nigeria
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Source of Support: None, Conflict of Interest: None


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Background: Pregnancy induced hypertension and preeclampsia (hypertension in pregnancy in association with the excretion of >300 mg of urinary protein per day after 20 weeks of gestation) is one of the most common complications of pregnancy seen in Benin City, Nigeria. It contributes significantly to maternal mortality, premature birth, intrauterine growth retardation and perinatal mortality. Studies have been performed to evaluate the role of electrolytes in etiopathogenesis of pregnancy induced hypertension and preeclampsia. The outcome of the studies has varied ina different environment and population. Objective: The objectiveof this study is to determine the role of serum sodium, potassium, magnesium and calcium in etiopathogenesis of preeclampsia in this environment. Materials and Methods: A total of 60 subjects were involved in the study. 20 were normotensive non-pregnant women, 20 normotensive pregnant women, 20 with preeclampsia. They were of similar age groups, with singleton pregnancies and in the second and third trimester of pregnancy. Serum sodium, potassium, calcium, magnesium was assayed in the three groups. Serum sodium and potassium was assayed using the ion-selective electrode method. Statistical analysis was done using SPSS Student Version 13 for Windows. Results: Mean serum sodium was non-significantly raised in women with preeclampsia above the upper limit of normal reference interval (151 ± 1.5 mmol/l) (P > 0.05) while it was within normal reference interval of 140 ± 2.3 mmol/L for normotensive pregnant women and 144 ± 4.2 mmol/L for normotensive non-pregnant women. Serum potassium, calcium, magnesium were all within normal reference intervals across the three groups studied. Conclusion: Serum sodium, potassium, calcium, magnesium do not seem to play a vital role in the etiopathogenesis of preeclampsia in this environment as there was no statistically significant difference in the values of the electrolytes assayed across the three groups studied.


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